Carvedilol, Endoscopic Variceal Ligation or Combination of Both for Prevention of First Variceal Bleed in Child's B & C Cirrhosis

Unknown 330 enrolled Institute of Liver and Biliary Sciences, India

RandomizedParallel-groupOpen-labelTreatment

Summary

Study Design: Open labeled randomized controlled trial. The study will be conducted on patients attending outpatient or admitted to admitted to Department of Hepatology from January 2017 to December 2018 at ILBS, New Delhi

Timeline

Start: 2017-03-15
Primary completion: 2020-11-30
Completion: 2020-11-30

Outcome

Met primary endpoint

paper significantly reduced the incidence of first variceal bleed by 62.9% as compared with group B (HR 0.37, 95% CI 0.192 to 0.716, p<0.003) PMID 39067870 ↗

paper by 69.3% as compared with group A (HR 0.31, 95% CI 0.163 to 0.578, <0.001) PMID 39067870 ↗

Publications

Tevethia HV, Pande A, Vijayaraghavan R, Kumar G, Sarin SK. Combination of carvedilol with variceal band ligation in prevention of first variceal bleed in Child-Turcotte-Pugh B and C cirrhosis with high-risk oesophageal varices: the 'CAVARLY TRIAL'. Gut. 2024 Oct 7;73(11):1844-1853. doi: 10.1136/gutjnl-2023-331181.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Carvedilol	Other / unclassified	12.5 mg	—