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drugset / Trial / NCT03076021

Effects of Isotretinoin on CYP2D6 Activity

NCT03076021 ↗

Phase 4 Completed 33 enrolled University of Washington National Institute of General Medical Sciences (NIGMS) · collab

NaSingle-groupOpen-labelOther

Summary

Specific Aim: To investigate if isotretinoin (13-cis-retinoic acid) administration decreases CYP2D6 activity in adolescent patients.

Timeline

Start: 2016-07-26
Primary completion: 2023-11-27
Completion: 2023-11-27

Publications

Results Zhao Y, Vary JC Jr, Yadav AS, Czuba LC, Shum S, LaFrance J, Huang W, Isoherranen N, Hebert MF. Effect of isotretinoin on CYP2D6 and CYP3A activity in patients with severe acne. Br J Clin Pharmacol. 2024 Mar;90(3):759-768. doi: 10.1111/bcp.15938. Epub 2023 Nov 21.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dextromethorphan	Unknown	30 mg	Oral
Subject	Isotretinoin	Other / unclassified	—	—

Indications

No indication recorded.