drugset / Trial / NCT03077607
A Study to Evaluate the Effect of Itraconazole and Rifampin on the Pharmacokinetics of Talazoparib in Patients With Advanced Solid Tumors
Non-randomizedOpen-labelTreatment
Summary
This is a study in patients with advanced solid tumors for the investigation of P-gp inhibition and induction on the PK of talazoparib.
Timeline
- Start
- 2016-11-07
- Primary completion
- 2017-12-19
- Completion
- 2018-01-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Itraconazole | Small molecule | 100 mg | Oral |
| Subject | Rifampin | Small molecule | 600 mg | Oral |
| Subject | Talazoparib | Small molecule | 0.5 mg | Oral |
| Subject | Talazoparib | Small molecule | 1 mg | Oral |