Salvational Intervention for Reducing AECOPD Under Severe Air Pollution

Summary

This is a multi-center, prospective, randomized and standard treatment parallel control clinical trial.A total of 764 stable COPD patients according to GOLD will be recruited and equally divided into two parallel groups, salvational intervention group (SI group) and control group (CT group).On the foundation of basic medicine, inhaled ICS/LABA will be used as an intervention drug for patients in SI group on severe air pollution days. It is aimed to evaluate whether this novel treatment strategy will decrease the frequency of AECOPD per year.

Timeline

Start

2017-03-20

Primary completion

2022-03-16

Completion

2022-03-16

Publications

• Zhou T, Zhong Y, Liao J, Wang G, Li X, Qian X, Xiang P, Chen X, Xu Z, Zhang F, Wang X, Wang S, Li X, Yu C, Zhang Y, Xia G, Dai L. A prospective study of salvational intervention with ICS/LABA for reducing chronic obstructive pulmonary disease exacerbation under severe air pollution (SIRCAP) in Beijing: protocol of a multi-center randomized controlled trial. BMC Pulm Med. 2019 Jan 25;19(1):22. doi: 10.1186/s12890-018-0771-9.

Drugs

Indications