drugset / Trial / NCT03083782

Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus

NCT03083782

RandomizedCrossoverOpen-labelBasic science

Summary

This study aims to evaluate the pharmacokinetics (PK) of apixaban when co-administered with cyclosporine and tacrolimus in healthy volunteers. The study participants will receive apixaban alone, cyclosporine followed by apixaban and tacrolimus followed by apixaban.

Timeline

Start
2017-04-18
Primary completion
2017-06-05
Completion
2017-06-30

Drugs

EvaluationDrugModalityDoseRoute
Comparator Apixaban Small molecule 10 mg Oral
Background Cyclosporine Peptide 100 mg Oral
Background Tacrolimus Small molecule 5 mg Oral