drugset / Trial / NCT03083782
Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus
RandomizedCrossoverOpen-labelBasic science
Summary
This study aims to evaluate the pharmacokinetics (PK) of apixaban when co-administered with cyclosporine and tacrolimus in healthy volunteers. The study participants will receive apixaban alone, cyclosporine followed by apixaban and tacrolimus followed by apixaban.
Timeline
- Start
- 2017-04-18
- Primary completion
- 2017-06-05
- Completion
- 2017-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Apixaban | Small molecule | 10 mg | Oral |
| Background | Cyclosporine | Peptide | 100 mg | Oral |
| Background | Tacrolimus | Small molecule | 5 mg | Oral |