Endostar Combined With Concurrent Chemoradiotherapy For Locally Advanced Cervical Carcinoma

Summary

A total of 120 patients with pathologically confirmed Locally advanced cervical carcinoma were enrolled. Patients were randomly divided into two groups, with 60 patients in each group. One group was treated with Concurrent Chemoradiotherapy combined with Endostar and the other group was treated with Concurrent Chemoradiotherapy. The short term efficacy and the toxic of these treatments were evaluated. The 1-year, 3-year, 5-year overall survival and progression-free survival of patients were analyzed. The investigators data may provide an alternative option for the treatment of Locally advanced cervical carcinoma with high efficacy and low toxicity.

Timeline

Start

2017-04-20

Primary completion

2020-09-30

Completion

2020-09-30

Publications

• Wu F, Tang X, Liu W, Luo Z, Huang H, Liu M, Wang H, Liao S, Ma S, Jiang L, Zhang Y. Efficacy of Endostar plus concurrent chemoradiotherapy in locally advanced cervical cancer: a multicenter, phase II randomized trial. Ther Adv Med Oncol. 2025 Oct 3;17:17588359251379397. doi: 10.1177/17588359251379397. eCollection 2025.

Drugs

Indications