drugset / Trial / NCT03087110
Stem Cells in Umbilical Blood Infusion for CP
Phase 1
Completed
12 enrolled
Murdoch Childrens Research Institute
Cerebral Palsy Alliance · collabChildren's Health Queensland · collabMonash Health · collabRoyal Children's Hospital · collabSydney Children's Hospitals Network · collab
NaSingle-groupOpen-labelTreatment
Summary
This study will investigate the safety of single dose intravenous infusion of cord blood cells which were cryopreserved after the birth of a brother or sister to a child with cerebral palsy.
Timeline
- Start
- 2016-03
- Primary completion
- 2019-09
- Completion
- 2020-12
Publications
- Crompton K, Novak I, Fahey M, Badawi N, Lee KJ, Mechinaud-Heloury F, Edwards P, Colditz P, Soosay Raj T, Hough J, Wang X, Paget S, Hsiao KC, Anderson P, Reddihough D. Safety of sibling cord blood cell infusion for children with cerebral palsy. Cytotherapy. 2022 Sep;24(9):931-939. doi: 10.1016/j.jcyt.2022.01.003. Epub 2022 Feb 19.
- Crompton K, Novak I, Fahey M, Badawi N, Wallace E, Lee K, Mechinaud-Heloury F, Colditz PB, Elwood N, Edwards P, Reddihough D. Single group multisite safety trial of sibling cord blood cell infusion to children with cerebral palsy: study protocol and rationale. BMJ Open. 2020 Mar 8;10(3):e034974. doi: 10.1136/bmjopen-2019-034974.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | cord blood cells | Cell therapy | 1e+07 cells/kg | Intravenous |