Effects of Exercise and Nicotine on Cognition in Smokers

Summary

Adult smokers will participate in a two stage testing trial, where the first stage will utilize a within-subject counterbalance design and individuals will participate in both conditions. The second stage will utilize a two-arm randomized control trail. The two conditions are (a) moderate intensity exercise and (b) nicotine inhalation. The primary measure of assessment will be reaction time and accuracy on the N-back task.

Timeline

Start

2017-05-01

Primary completion

2018-04-01

Completion

2024-05-01

Publications

• Background Heishman SJ, Kleykamp BA, Singleton EG. Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology (Berl). 2010 Jul;210(4):453-69. doi: 10.1007/s00213-010-1848-1. Epub 2010 Apr 24.
• Background Hughes JR. Effects of abstinence from tobacco: etiology, animal models, epidemiology, and significance: a subjective review. Nicotine Tob Res. 2007 Mar;9(3):329-39. doi: 10.1080/14622200701188927.
• Background Jonides J, Schumacher EH, Smith EE, Lauber EJ, Awh E, Minoshima S, Koeppe RA. Verbal Working Memory Load Affects Regional Brain Activation as Measured by PET. J Cogn Neurosci. 1997 Jul;9(4):462-75. doi: 10.1162/jocn.1997.9.4.462.
• Background Stolz D, Scherr A, Seiffert B, Kuster M, Meyer A, Fagerstrom KO, Tamm M. Predictors of success for smoking cessation at the workplace: a longitudinal study. Respiration. 2014;87(1):18-25. doi: 10.1159/000346646. Epub 2013 Apr 10.

Drugs

Indications

No indication recorded.