drugset / Trial / NCT03093090

Evaluating Predictive Methods & Product Performance in Healthy Adults for Pediatric Patients, A Case Study: Furosemide

NCT03093090

Phase 1 Withdrawn Yale University
RandomizedCrossoverOpen-labelBasic science

Summary

Poorly absorbed medications such as furosemide are common and recent experiments suggest that improvement in absorption can occur if these types of medications are consumed with liquids such as milk. The purpose of this study is to evaluate the absorption of furosemide in normal adults when taken with bottled water, milk (Parmalat™ Whole Milk), baby formula (Similac Pro-Advance™), or Ensure Plus™. These results will be used to make models that predict how these liquids will affect drug absorption in children, potentially providing ways to improve medication absorption in children.

Timeline

Start
2018-12-31
Primary completion
2019-06-01
Completion
2019-06-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Furosemide Other / unclassified 20 mg Oral

Indications

No indication recorded.