drugset / Trial / NCT03095547
Drug/Drug Interactions With F901318
RandomizedParallel-groupOpen-labelTreatment
Summary
Study of interactions between F901318 and multiple doses of posaconazole and pantoprazole and single doses of cyclosporine A and tacrolimus in healthy subjects. Pharmacokinetic (PK) profiles, safety and tolerability will be assessed.
Timeline
- Start
- 2017-05
- Primary completion
- 2017-07
- Completion
- 2017-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cyclosporine | Peptide | 100 mg | — |
| Subject | Olorofim | Small molecule | 120 mg | — |
| Subject | Olorofim | Small molecule | 240 mg | — |
| Subject | Olorofim | Small molecule | 360 mg | — |
| Subject | Pantoprazole | Other / unclassified | 40 mg | — |
| Subject | Posaconazole | Small molecule | 300 mg | — |
| Subject | Tacrolimus | Small molecule | 2 mg | — |