PET Study to Determine Muscarinic Receptor Occupancy in Lungs After Inhalation of AZD2115 and Tiotropium

Summary

An open-label study using positionemissiontomography (PET) to explore the binding of AZD2115 and Tiotropium to muscarinic receptors in the lungs in healthy volunteers after inhalation.

Timeline

Start

2017-04-26

Primary completion

2017-12-30

Completion

2017-12-30

Publications

• Cselenyi Z, Jucaite A, Ewing P, Stenkrona P, Kristensson C, Johnstrom P, Schou M, Bolin M, Halldin C, Larsson B, Grime K, Eriksson UG, Farde L. Proof of lung muscarinic receptor occupancy by tiotropium: Translational Positron Emission Tomography studies in non-human primates and humans. Front Nucl Med. 2023 Jan 18;2:1080005. doi: 10.3389/fnume.2022.1080005. eCollection 2022.
• Cselenyi Z, Jucaite A, Kristensson C, Stenkrona P, Ewing P, Varrone A, Johnstrom P, Schou M, Vazquez-Romero A, Moein MM, Bolin M, Siikanen J, Gryback P, Larsson B, Halldin C, Grime K, Eriksson UG, Farde L. Quantification and reliability of [11C]VC - 002 binding to muscarinic acetylcholine receptors in the human lung - a test-retest PET study in control subjects. EJNMMI Res. 2020 Jun 3;10(1):59. doi: 10.1186/s13550-020-00634-0.

Drugs

Indications

No indication recorded.