drugset

drugset / Trial / NCT03098563

Maximizing Analgesia to Reduce Pain in Knee Osteoarthritis

NCT03098563 ↗

Phase 2 Completed 58 enrolled Johns Hopkins University National Institute on Drug Abuse (NIDA) · collab

RandomizedCrossoverTriple-blindBasic science

Summary

This research is being done to evaluate whether combining medications that are FDA approved, but have not yet been approved for combination treatment, can be effective in reducing pain.

Timeline

Start: 2017-11-01
Primary completion: 2023-11-17
Completion: 2023-11-27

Publications

Hamilton KR, Mun CJ, Sadik E, Bergeria CL, Huhn AS, Speed TJ, Vandrey R, Dunn KE, Campbell CM. Evaluating the Acute Effects of the Cannabinoid Dronabinol and the Opioid Hydromorphone Alone and in Combination: A Double-blind, Randomized, Placebo-controlled Trial in Knee Osteoarthritis. Anesthesiology. 2026 May 1;144(5):1187-1198. doi: 10.1097/ALN.0000000000005925. Epub 2025 Dec 31.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Dronabinol	Other / unclassified	10 mg	Oral
Subject	Hydromorphone	Other / unclassified	2 mg	Oral

Indications