drugset / Trial / NCT03100058
A Study to Evaluate the Change in Weight After 24 Weeks Treatment With LIK066 in Obese or Overweight Adults
RandomizedParallel-groupTriple-blindTreatment
Summary
This was a dose-finding study that evaluated the change in weight after 24 weeks treatment with 8 different doses of LIK066 compared to placebo in obese or overweight adults, followed by 24 weeks treatment with 2 doses of LIK066 and placebo.
Timeline
- Start
- 2017-05-06
- Primary completion
- 2018-03-02
- Completion
- 2018-08-02
Outcome
Met primary endpoint
registry analysis (other test); LIK066 2.5mg qd (Epoch 3) vs Placebo (Epoch 3); p <0.0001; Mean Difference (Net) -1.73 (95% CI -3.17 to -0.29); ANCOVA NCT03100058 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | licogliflozin | Small molecule | 2.5 mg | Oral |
| Subject | licogliflozin | Small molecule | 5 mg | Oral |
| Subject | licogliflozin | Small molecule | 10 mg | Oral |
| Subject | licogliflozin | Small molecule | 25 mg | Oral |
| Subject | licogliflozin | Small molecule | 35 mg | Oral |
| Subject | licogliflozin | Small molecule | 50 mg | Oral |
| Subject | licogliflozin | Small molecule | 150 mg | Oral |