drugset / Trial / NCT03103568
A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers
Non-randomizedSequentialOpen-labelBasic science
Summary
An open-label, non-randomized, 2-arm, 2-period fixed sequence phase 1 study to evaluate the potential inhibition of nitisinone on cytochrome P450 2C9, 2D6, and 2E1 and the organic anion transporters OAT1 and OAT3 in healthy volunteers
Timeline
- Start
- 2017-03-28
- Primary completion
- 2017-06-10
- Completion
- 2017-07-24
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Chlorzoxazone | Small molecule | 250 mg | Oral |
| Subject | Furosemide | Other / unclassified | 20 mg | Intravenous |
| Subject | Metoprolol | Other / unclassified | 50 mg | Oral |
| Subject | Nitisinone | Small molecule | 80 mg | Oral |
| Subject | Tolbutamide | Small molecule | 500 mg | Oral |
Indications
No indication recorded.