drugset / Trial / NCT03112577

Study of REGN3500 and Dupilumab in Patients With Asthma

NCT03112577

Phase 1 Completed 32 enrolled Regeneron Pharmaceuticals Sanofi · collab
RandomizedParallel-groupQuadruple-blindTreatment

Summary

To assess the effects of REGN3500, dupilumab, and REGN3500 plus dupilumab, compared with placebo, on changes in inflammatory gene expression signatures in sputum induced after a bronchial allergen challenge (BAC) in adults with mild allergic asthma, at week 4 after treatment initiation compared with those at screening.

Timeline

Start
2017-06-15
Primary completion
2019-03-20
Completion
2019-12-09

Drugs

EvaluationDrugModalityDoseRoute
Subject Dupilumab Monoclonal antibody Subcutaneous
Comparator Fluticasone propionate Other / unclassified Inhaled
Subject Itepekimab Monoclonal antibody Intravenous

Indications