drugset / Trial / NCT03112577
Study of REGN3500 and Dupilumab in Patients With Asthma
RandomizedParallel-groupQuadruple-blindTreatment
Summary
To assess the effects of REGN3500, dupilumab, and REGN3500 plus dupilumab, compared with placebo, on changes in inflammatory gene expression signatures in sputum induced after a bronchial allergen challenge (BAC) in adults with mild allergic asthma, at week 4 after treatment initiation compared with those at screening.
Timeline
- Start
- 2017-06-15
- Primary completion
- 2019-03-20
- Completion
- 2019-12-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dupilumab | Monoclonal antibody | — | Subcutaneous |
| Comparator | Fluticasone propionate | Other / unclassified | — | Inhaled |
| Subject | Itepekimab | Monoclonal antibody | — | Intravenous |