drugset / Trial / NCT03118024
Perioperative Management of DIEP Flaps
RandomizedParallel-groupTriple-blindTreatment
Summary
By comparison of two different protocols with diverse fluid/ catecholamine administration limits (fluid restriction vs. catecholamine restriction with target systolic blood pressure \> 100 mmHg) the investigators would like to reveal the impact of intraoperative blood pressure management on the survival rate of free deep inferior epigastric artery flaps for breast reconstruction.
Timeline
- Start
- 2017-03-13
- Primary completion
- 2019-03
- Completion
- 2019-03
Publications
- Background Eley KA, Young JD, Watt-Smith SR. Epinephrine, norepinephrine, dobutamine, and dopexamine effects on free flap skin blood flow. Plast Reconstr Surg. 2012 Sep;130(3):564-570. doi: 10.1097/PRS.0b013e31825dbf73.
- Background Motakef S, Mountziaris PM, Ismail IK, Agag RL, Patel A. Emerging paradigms in perioperative management for microsurgical free tissue transfer: review of the literature and evidence-based guidelines. Plast Reconstr Surg. 2015 Jan;135(1):290-299. doi: 10.1097/PRS.0000000000000839.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Noradrenaline | Unknown | 0.04 ug/kg | — |
| Comparator | Noradrenaline | Unknown | 0.15 ug/kg | — |
Indications
No indication recorded.