drugset / Trial / NCT03136497
A Study of ABT-199 Plus Ibrutinib and Rituximab in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma
Phase 1
Terminated
10 enrolled
Hackensack Meridian Health
Genentech, Inc. · collabJanssen Scientific Affairs, LLC · collab
Non-randomizedSequentialOpen-labelTreatment
Summary
A Study of Venetoclax Plus Ibrutinib and Rituximab in Patients with Relapsed/Refractory Diffuse Large B-cell Lymphoma (DLBCL). Our hypothesis is that the combination therapy of BTK (Bruton's tyrosine kinase) Inhibitor Ibrutinib plus Venetoclax and Rituximab in relapsed or refractory DLBCL will have an increased activity with acceptable toxicity. Furthermore, this new novel therapeutic combination will be safe and well tolerated among this patient population.
Timeline
- Start
- 2017-09-05
- Primary completion
- 2020-11-09
- Completion
- 2020-11-09
Publications
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Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Venetoclax | Small molecule | 400 mg | Oral |
| Subject | Venetoclax | Small molecule | 800 mg | Oral |
| Background | Ibrutinib | Small molecule | — | Oral |
| Background | Rituximab | Monoclonal antibody | — | Intravenous |