Evaluation of Platelet Rich Plasma (PRP) for Knee Osteoarthritis

Phase 2 Unknown 60 enrolled University of Sao Paulo RDO Laboratory · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Study was designed to evaluate efficacy of autologous platelet rich plasma (PRP) injections guided by ultrasound for treatment of knee osteoarthritis.

Timeline

Start: 2017-01-02
Primary completion: 2018-05-30
Completion: 2018-05-30

Outcome

Missed primary endpoint

paper PRP and plasma were not superior to placebo for pain and function improvement in KOA over 24 weeks. PMID 34560869 ↗

Publications

Dorio M, Pereira RMR, Luz AGB, Deveza LA, de Oliveira RM, Fuller R. Efficacy of platelet-rich plasma and plasma for symptomatic treatment of knee osteoarthritis: a double-blinded placebo-controlled randomized clinical trial. BMC Musculoskelet Disord. 2021 Sep 24;22(1):822. doi: 10.1186/s12891-021-04706-7.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	PRP	Unknown	6 ml	Other
Subject	Plasma	Other / unclassified	6 ml	Other