Metoprolol to Reduce Perioperative Myocardial Injury

Phase 3 Completed 72 enrolled University of Chicago National Heart, Lung, and Blood Institute (NHLBI) · collab Washington University School of Medicine · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

The purpose of this research study is to test if a commonly used, FDA-approved medication, called metoprolol, given at the conclusion of anesthesia following surgery, and during postoperative admission, reduces the possibility of heart related complications in patients with coronary artery disease (CAD).

Timeline

Start: 2016-12
Primary completion: 2023-04-18
Completion: 2023-08-29

Publications

Nagele P, Helwani MA, Samaha E, Kokofer A, Brown F, Karrison T, Gage BF, Brown-Shpigel JC, Rubin DS. A Combined Intravenous and Oral Metoprolol Regimen to Reduce Perioperative Myocardial Injury: The ORION Trial. Anesth Analg. 2026 May 1;142(5):1009-1012. doi: 10.1213/ANE.0000000000007789. Epub 2026 Apr 14. No abstract available.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Metoprolol	Other / unclassified	25 mg	Intravenous

Metoprolol to Reduce Perioperative Myocardial Injury

Summary

Timeline

Publications

Drugs

Indications