Opioid Analgesia for MAB

Summary

Our primary objective will be to determine if a strong opioid, oxycodone, given at a dose recommended for severe pain in addition to ibuprofen decreases maximum pain scores compared to ibuprofen and placebo in women undergoing medical abortion (MAB). Results of this study will help future providers understand whether prescribing opioids are an important adjunct for pain control in women undergoing MAB.

Timeline

Start

2017-05-01

Primary completion

2018-05-31

Completion

2018-05-31

Outcome

Missed primary endpoint

paper We found no difference between groups in median maximum pain scores (placebo 8 [range 1-10], oxycodone 8 [range 2-10], P=.92) PMID 31764725 ↗

paper Oxycodone does not reduce the maximum level of pain experienced by women undergoing medical abortion up to 10 0/7 weeks of gestation PMID 31764725 ↗

Publications

• Colwill AC, Bayer LL, Bednarek P, Garg B, Jensen JT, Edelman AB. Opioid Analgesia for Medical Abortion: A Randomized Controlled Trial. Obstet Gynecol. 2019 Dec;134(6):1163-1170. doi: 10.1097/AOG.0000000000003576.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxycodone	Other / unclassified	10 mg	Oral

Indications

No indication recorded.