Oxytocin Dosage to Decrease Induction Duration

Phase 4 Completed 140 enrolled University of Arizona

RandomizedParallel-groupQuadruple-blindOther

Summary

This is a randomized controlled trial in which women are allocated either 'high dose' or 'low dose' oxytocin infusions for induction of labour. The randomization is stratified by maternal body mass index.

Timeline

Start: 2017-06-05
Primary completion: 2018-10-12
Completion: 2019-09-05

Outcome

Missed primary endpoint

paper The primary outcome, time to vaginal delivery, was similar between the low-dose and high-dose oxytocin groups PMID 35358738 ↗

paper the stratum with obesity (715 [±497] vs 762 [±594] minutes; P=.733). PMID 35358738 ↗

Publications

Wei RM, Bounthavong M, Hill MG. High- vs low-dose oxytocin in lean and obese women: a double-blinded randomized controlled trial. Am J Obstet Gynecol MFM. 2022 Jul;4(4):100627. doi: 10.1016/j.ajogmf.2022.100627. Epub 2022 Mar 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxytocin	Peptide	30 iu	—
Subject	Oxytocin	Peptide	90 iu	—