drugset
drugset / Trial / NCT03151707

The Effects of Nicotinamide Riboside Supplementation on Brain NAD+/NADH Ratio and Bioenergetics

NCT03151707 ↗

Phase 4 Terminated 11 enrolled Mclean Hospital
NaSingle-groupOpen-labelTreatment

Summary

The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain NAD+/NADH ratio and bioenergetics functions in healthy individuals using phosphorus magnetic resonance spectroscopy (31P MRS) imaging. The secondary aims are to investigate the change in brain PCr/ATP and creatine kinase enzyme rate after NR use. In addition, NAD+/NADH ratio, PCr/ATP and CK enzyme rate will be measured in the calf muscle, as secondary outcome measures.

Timeline

Start
2017-10-01
Primary completion
2022-09-30
Completion
2022-09-30

Drugs

EvaluationDrugModalityDoseRoute
Subject Nicotinamide riboside Small molecule 2 g —

Indications

No indication recorded.