drugset / Trial / NCT03156673
Treatment of COPD by Autologous Transplantation of Bronchial Basal Cells
Phase 0
Unknown
20 enrolled
First Affiliated Hospital of Shantou University Medical College
Regend Therapeutics · collabTongji University · collab
NaSingle-groupOpen-labelTreatment
Summary
Bronchial basal cells are proved to be able to regenerate lung structures to repair the injured lung. In COPD patients, bronchus structures are injured and cannot be repaired, which may result in the failure of pulmonary function rescue clinically.In our research, autologous bronchial basal cells will be transplanted into lung of patients suffered with COPD to treat the disease. Specifically, autologous bronchial basal cells will be dissected from brushed-off samples by bronchofiberscope. Then, they will be expanded in vitro and transplanted into lung to regenerate new alveoli and bronchus structures and re-establish pulmonary system.
Timeline
- Start
- 2017-04-01
- Primary completion
- 2021-12-31
- Completion
- 2022-06-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bronchial basal cells | Cell therapy | 1e+06 cells/kg | Other |