Prophylactic Antibiotics After Cesarean

Phase 1 Completed 321 enrolled The University of Texas Medical Branch, Galveston

RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to determine if the addition of a 48-hour course of post-operative antibiotics to the recommended course of pre-operative antibiotics improves surgical site infection rate in patients who are obese and undergo Cesarean section after laboring.

Timeline

Start: 2017-08-01
Primary completion: 2023-07-21
Completion: 2023-07-21

Outcome

Missed primary endpoint

paper did not significantly lower the rate of infection complications within 30 days after delivery. PMID 40403315 ↗

paper odds ratio 0.81, 95% CI, 0.33-2.02; P =.64 PMID 40403315 ↗

Publications

Saad AF, Goldman B, Spencer N, Kuhlmann M, McDonnold M, Saade GR. Prophylactic Oral Cephalexin and Metronidazole Compared With Placebo After Cesarean Delivery to Reduce Infection Complications in Women With Obesity: A Randomized Controlled Trial. Obstet Gynecol. 2025 May 22;146(1):113-120. doi: 10.1097/AOG.0000000000005936.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	CEPHALEXIN ANHYDROUS	Small molecule	500 mg	Oral
Subject	Metronidazole	Small molecule	500 mg	Oral

Indications

No indication recorded.