drugset / Trial / NCT03192020
Trial Comparing Treatment Strategies in Dupuytren's Contracture
Phase 4
Active not recruiting
302 enrolled
Tampere University
Central Finland Hospital District · collabFinnish Institute for Health and Welfare · collabHelsinki University Central Hospital · collabKuopio University Hospital · collabMedcare Oy · collabOrton Orthopaedic Hospital · collabOulu University Hospital · collabTampere University Hospital · collabTurku University Hospital · collab
RandomizedParallel-groupDouble-blindTreatment
Summary
Trial is a prospective, randomized, controlled, outcome assessor-blinded, three armed parallel 1:1:1, multicenter trial. The research objective is to determine, which treatment strategy 1) primary percutaneous needle fasciotomy (PNF) followed by surgical limited fasciectomy (LF) in patients who do not respond to PNF, 2) primary collagenase clostridium histolyticym (CCH) followed by LF in patients who do not respond to CCH or 3) LF as the primary (and secondary) treatment modality is the most cost-effective in treating Dupuytren´s contracture. Short- and long-term results will be published.
Timeline
- Start
- 2017-09-15
- Primary completion
- 2026-05-31
- Completion
- 2031-05-31
Publications
- Background Raisanen MP, Karjalainen T, Goransson H, Reito A, Kautiainen H, Malmivaara A, Leppanen OV. DupuytrEn Treatment EffeCtiveness Trial (DETECT): a protocol for prospective, randomised, controlled, outcome assessor-blinded, three-armed parallel 1:1:1, multicentre trial comparing the effectiveness and cost of collagenase clostridium histolyticum, percutaneous needle fasciotomy and limited fasciectomy as short-term and long-term treatment strategies in Dupuytren's contracture. BMJ Open. 2018 Mar 28;8(3):e019054. doi: 10.1136/bmjopen-2017-019054.
- Results Raisanen MP, Leppanen OV, Soikkeli J, Reito A, Malmivaara A, Buchbinder R, Kautiainen H, Kaivorinne A, Stjernberg-Salmela S, Lappalainen M, Luokkala T, Ponkko A, Taskinen HS, Paakkonen M, Jaatinen K, Juurakko J, Karjalainen VL, Karjalainen T. Surgery, Needle Fasciotomy, or Collagenase Injection for Dupuytren Contracture : A Randomized Controlled Trial. Ann Intern Med. 2024 Mar;177(3):280-290. doi: 10.7326/M23-1485. Epub 2024 Feb 13.
- Karjalainen VL, Soikkeli J, Raisanen MP, Leppanen OV, Reito A, Stjernberg-Salmela S, Buchbinder R, Karjalainen T. Progression of Dupuytren Contracture: A Randomized Controlled Trial Comparing Surgery, Needle Fasciotomy, and Collagenase Injection. Plast Reconstr Surg. 2026 Jul 1;158(1):101-112. doi: 10.1097/PRS.0000000000012666. Epub 2025 Dec 4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Collagenase Clostridium Histolyticum | Protein / enzyme biologic | 0.58 mg | Other |