A Safety and Efficacy Study of ChAdOx1 LS2 and MVA LS2

Summary

The purpose of this study is to assess the safety, immunogenicity and efficacy of the candidate malaria vaccines ChAdOx1 LS2 and MVA LS2. Healthy adult volunteers will be recruited and vaccinated in Oxford.

Timeline

Start

2017-07-03

Primary completion

2017-12-20

Completion

2017-12-20

Publications

• Silman D, Flaxman A, Datoo M, Edwards NJ, Ramos-Lopez F, Mitton C, Mair C, Bellamy D, Bowyer G, Morter R, Halbroth B, Venkatraman N, Folegatti PM, Marshall J, Poulton I, Bajer A, Salman AM, Berrie E, Baum J, Blagborough AM, Crocker W, Roberts R, Lawrie AM, Spencer AJ, Gilbert SC, Ewer KJ, Hill AVS. Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naive adults. Wellcome Open Res. 2026 Apr 6;9:734. doi: 10.12688/wellcomeopenres.22900.2. eCollection 2024.

Drugs

Indications