Physiological Study of the Human CYP3A Activity (PiSA)

Summary

Investigator-initiated physiological study to characterize the function of a major drug metabolizing enzyme using a microdosed phenotyping probe to avoid unwanted, concentration-dependent effects.

Timeline

Start

2017-08-18

Primary completion

2017-09-25

Completion

2017-09-25

Publications

• Kiene K, Hayasi N, Burhenne J, Uchitomi R, Sunderhauf C, Schmid Y, Haschke M, Haefeli WE, Krahenbuhl S, Mikus G, Inada H, Huwyler J. Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film. Eur J Pharm Sci. 2019 Jul 1;135:77-82. doi: 10.1016/j.ejps.2019.05.010. Epub 2019 May 16.

Drugs

Indications

No indication recorded.