Effect of Medical Marijuana on Neurocognition and Escalation of Use

Summary

This study will use a randomized controlled design to test whether patients who use medical marijuana, compared to a waitlist control group, experience a change in health outcomes (relief of symptoms, or adverse health outcomes such as new-onset symptoms of cannabis use disorders, neurocognitive impairments) or brain-based changes.

Timeline

Start

2017-07-01

Primary completion

2021-02-05

Completion

2022-11-01

Publications

• Burdinski D, Kodibagkar A, Potter K, Schuster R, Evins AE, Ghosh S, Gilman J. Impact of year-long cannabis use for medical symptoms on brain activation during cognitive processes. medRxiv [Preprint]. 2024 May 1:2024.04.29.24306516. doi: 10.1101/2024.04.29.24306516.
• Livne O, Potter KW, Schuster RM, Gilman JM. Longitudinal Associations Between Cannabis Use and Cognitive Impairment in a Clinical Sample of Middle-Aged Adults Using Cannabis for Medical Symptoms. Cannabis Cannabinoid Res. 2024 Jun;9(3):e933-e938. doi: 10.1089/can.2022.0310. Epub 2023 Aug 25.
• Weiss JH, Tervo-Clemmens B, Potter KW, Evins AE, Gilman JM. The Cannabis Effects Expectancy Questionnaire-Medical (CEEQ-M): Preliminary psychometric properties and longitudinal validation within a clinical trial. Psychol Assess. 2023 Aug;35(8):659-673. doi: 10.1037/pas0001244. Epub 2023 Jun 8.
• Gilman JM, Potter K, Schuster RM, Hoeppner BB, Evins AE. Cannabis use for medical symptoms: Patterns over the first year of use. Addict Behav. 2023 Sep;144:107719. doi: 10.1016/j.addbeh.2023.107719. Epub 2023 Apr 13.
• Tervo-Clemmens B, Schmitt W, Wheeler G, Cooke ME, Schuster RM, Hickey S, Pachas GN, Evins AE, Gilman JM. Cannabis use and sleep quality in daily life: An electronic daily diary study of adults starting cannabis for health concerns. Drug Alcohol Depend. 2023 Feb 1;243:109760. doi: 10.1016/j.drugalcdep.2022.109760. Epub 2022 Dec 29.
• Gilman JM, Schuster RM, Potter KW, Schmitt W, Wheeler G, Pachas GN, Hickey S, Cooke ME, Dechert A, Plummer R, Tervo-Clemmens B, Schoenfeld DA, Evins AE. Effect of Medical Marijuana Card Ownership on Pain, Insomnia, and Affective Disorder Symptoms in Adults: A Randomized Clinical Trial. JAMA Netw Open. 2022 Mar 1;5(3):e222106. doi: 10.1001/jamanetworkopen.2022.2106.

Drugs

Indications