Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers
Summary
This research study involves taking an experimental anti-cancer dietary supplement called Sulforaphane (SF) or a placebo (product without any supplement content) over a period of twelve months in order to determine if it is a useful dietary supplement for prevention of lung cancer in humans. The main goals of this research study are: 1. To learn about the effects of giving Sulforaphane (SF) to former smokers who are still at high risk of developing cancer due to their smoking history and whether or not their condition improves, stays the same or becomes worse after Sulforaphane (SF) is given. 2. To learn whether Sulforaphane (SF) might reverse some of the lung cell changes associated with future development of lung cancer.
Timeline
- Start
- 2018-01-25
- Primary completion
- 2023-02-17
- Completion
- 2023-02-17
Outcome
Mixed primary results
paper Supplementation of sulforaphane did not show significant impact on bronchial histopathology PMID 40041932 ↗
paper significantly reduced the Ki-67 index with a 20% decrease in the sulforaphane group and a 65% increase in the placebo (P = 0.014). PMID 40041932 ↗
paper Sulforaphane treatment had no impact on the caspase-3 or TUNEL index in bronchial biopsies. PMID 40041932 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Sulforaphane | Small molecule | 0.12 mmol | Oral |