Clinical Trial of Lung Cancer Chemoprevention With Sulforaphane in Former Smokers

Summary

This research study involves taking an experimental anti-cancer dietary supplement called Sulforaphane (SF) or a placebo (product without any supplement content) over a period of twelve months in order to determine if it is a useful dietary supplement for prevention of lung cancer in humans. The main goals of this research study are: 1. To learn about the effects of giving Sulforaphane (SF) to former smokers who are still at high risk of developing cancer due to their smoking history and whether or not their condition improves, stays the same or becomes worse after Sulforaphane (SF) is given. 2. To learn whether Sulforaphane (SF) might reverse some of the lung cell changes associated with future development of lung cancer.

Timeline

Start

2018-01-25

Primary completion

2023-02-17

Completion

2023-02-17

Publications

• Yuan JM, Kensler TW, Dacic S, Hartman DJ, Wang R, Balogh PA, Sufka P, Turner MA, Fuhrer K, Seigh L, Pham YT, Adams-Haduch J, Valacchi G, Singh SV, Herman JG, Wilson DO. Randomized Phase II Clinical Trial of Sulforaphane in Former Smokers at High Risk for Lung Cancer. Cancer Prev Res (Phila). 2025 Jun 2;18(6):335-345. doi: 10.1158/1940-6207.CAPR-24-0386.

Drugs

Indications