Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers

Phase 2 Completed 75 enrolled Cetylite Industries

RandomizedCrossoverDouble-blindPrevention

Summary

The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.

Timeline

Start: 2017-06-15
Primary completion: 2018-02-20
Completion: 2018-02-20

Publications

Hersh EV, Secreto S, Wang S, Giannakopoulos H, Mousavian M, Lesavoy B, Hutcheson MC, Farrar JT, Wang P, Doyle G, Cooper SA. A Proof-of-concept Study Using Quantitative Sensory Threshold Analysis to Compare Two Intraoral Topical Anesthetics. Clin Ther. 2019 Feb;41(2):291-302. doi: 10.1016/j.clinthera.2018.12.009. Epub 2019 Jan 17.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Benzocaine	Small molecule	28 mg	Topical
Subject	tetracaine	Other / unclassified	4 mg	Topical

Indications

No indication recorded.