Pharmacological Comparison of Continuous and Intermittent Infusions of Cloxacillin

Summary

Our objective is to establish pharmacological equivalence of intermittent and continuous infusion of cloxacillin during methicillin-susceptible Staphylococcus aureus (MSSA) bone and joint infections (BJI). Twelve patients suffering MSSA BJI will receive both administration modalities and serum concentrations of cloxacillin will be determined after 3 days of II and 3 days of continuous infusion in a prospective, randomized, open-label, monocentric crossover study design.

Timeline

Start

2017-11-23

Primary completion

2017-11-23

Completion

2018-09-18

Publications

• Background Courjon J, Garzaro M, Roger PM, Ruimy R, Lavrut T, Chelli M, Raynier JL, Chirio D, Demonchy E, Cabane L, Jehl F, Trojani C, Grillon A, Goutelle S. A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during Staphylococcus aureus Bone and Joint Infections. Antimicrob Agents Chemother. 2020 Nov 17;64(12):e01562-20. doi: 10.1128/AAC.01562-20. Print 2020 Nov 17.

Drugs

Indications