drugset / Trial / NCT03254589
Methotrexate, Blood Pressure and Arterial Function in Rheumatoid Arthritis
Phase 4
Completed
124 enrolled
Flinders University
University of South Australia · collabmedac GmbH · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The investigators will study the effects of methotrexate on blood pressure, arterial stiffness and endothelial function in patients with rheumatoid arthritis.
Timeline
- Start
- 2017-10-01
- Primary completion
- 2023-12-31
- Completion
- 2023-12-31
Outcome
Met primary endpoint
paper After six months, compared to Group 2, Group 1 patients had significantly lower SBP (-7.4 mmHg, 95% CI -14.0 to -0.8, p = 0.03). PMID 40742006 ↗
Publications
- Mangoni AA, Wiese MD, Woodman RJ, Sotgia S, Zinellu A, Carru C, Hulin JA, Shanahan EM, Tommasi S. A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis. Ann Med. 2025 Dec;57(1):2539311. doi: 10.1080/07853890.2025.2539311. Epub 2025 Jul 31.
- Mangoni AA, Wiese MD, Woodman RJ, Sotgia S, Zinellu A, Carru C, Hulin JA, Shanahan EM, Tommasi S. Methotrexate, blood pressure and arterial function in rheumatoid arthritis: study protocol. Future Cardiol. 2024;20(13):671-683. doi: 10.1080/14796678.2024.2411167. Epub 2024 Oct 10.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methotrexate | Small molecule | — | Subcutaneous |
| Comparator | Sulfasalazine | Small molecule | — | — |