Ketamine as an Adjunctive Therapy for Major Depression

Summary

Randomised, controlled, parallel-group, pilot clinical trial of ketamine vs. midazolam as an adjunctive therapy for depression. The main purpose of the pilot study is to assess trial processes to help inform a future definitive trial.

Timeline

Start

2017-09-07

Primary completion

2018-09-21

Completion

2018-09-21

Publications

• Gallagher B, Foley M, Slattery CM, Gusciute G, Shanahan E, McLoughlin DM. Ketamine as an adjunctive therapy for major depression - a randomised controlled pragmatic pilot trial (Karma-Dep Trial). HRB Open Res. 2022 Jan 27;3:90. doi: 10.12688/hrbopenres.13182.2. eCollection 2020.

Drugs

Indications