drugset / Trial / NCT03257722

Pembrolizumab + Idelalisib for Lung Cancer Study

NCT03257722

Non-randomizedSequentialOpen-labelTreatment

Summary

This is a phase 1b/2 study to determine the safety and effectiveness of the combination of pembrolizumab and idelalisib in NSCLC patients whose disease has stopped responding to immune therapy. This study is being done to see if adding another immune modulator (idelalisib) to standard pembrolizumab will increase response rates, compared to the response seen with pembrolizumab alone.

Timeline

Start
2017-09-26
Primary completion
2020-08-15
Completion
2021-08-25

Drugs

EvaluationDrugModalityDoseRoute
Subject Idelalisib Small molecule 50 mg Oral
Subject Idelalisib Small molecule 100 mg Oral
Subject Idelalisib Small molecule 150 mg Oral
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous