drugset / Trial / NCT03257722
Pembrolizumab + Idelalisib for Lung Cancer Study
Non-randomizedSequentialOpen-labelTreatment
Summary
This is a phase 1b/2 study to determine the safety and effectiveness of the combination of pembrolizumab and idelalisib in NSCLC patients whose disease has stopped responding to immune therapy. This study is being done to see if adding another immune modulator (idelalisib) to standard pembrolizumab will increase response rates, compared to the response seen with pembrolizumab alone.
Timeline
- Start
- 2017-09-26
- Primary completion
- 2020-08-15
- Completion
- 2021-08-25
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Idelalisib | Small molecule | 50 mg | Oral |
| Subject | Idelalisib | Small molecule | 100 mg | Oral |
| Subject | Idelalisib | Small molecule | 150 mg | Oral |
| Subject | Pembrolizumab | Monoclonal antibody | 200 mg | Intravenous |