drugset / Trial / NCT03259087

Pharmacokinetics (PK) and Safety of a Single Intravenous (IV) Dose of MK-3866 in Participants With Impaired Renal Function and in Healthy Controls (MK-3866-005)

NCT03259087 ↗

Phase 1 Completed 42 enrolled Merck Sharp & Dohme LLC
Non-randomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to compare plasma and urine PK parameters of MK-3866 between participants with impaired renal function and healthy control participants, to investigate the extent to which MK-3866 is removed from the plasma by hemodialysis (HD), and evaluate the safety and tolerability of MK-3866 in participants with impaired renal function.

Timeline

Start
2017-09-01
Primary completion
2018-01-28
Completion
2018-02-09

Drugs

EvaluationDrugModalityDoseRoute
Subject MK-3866 Unknown 200 mg Intravenous