HDAC Inhibitor Augmentation to Clozapine

Summary

The main goal of this pilot study is to test the extent to which adjunctive treatment with the histone deacetylase (HDAC) inhibitor vorinostat improves brain plasticity and cognition in a pilot placebo-controlled trial in patients with schizophrenia who are on clozapine.

Timeline

Start

2017-04

Primary completion

2019-02

Completion

2019-02

Outcome

Outcome not reported

Stopped (Enrollment): “PIs were unable to recruit any participants”

Drugs

Indications