Pembrolizumab Activity in Patients With Homologous Recombination Competent and Deficient Tumors

Summary

Phase II trial in which patients with metastatic solid tumors experiencing progression after first line standard chemotherapy or for which there is no standard chemotherapy, and for which pembrolizumab does not have an FDA or compendia listing approved indication, will receive pembrolizumab intravenously at a dose of 200 mg every 3 weeks.

Timeline

Start

2017-11-03

Primary completion

2020-10-20

Completion

2022-03-19

Publications

• Results Villalona-Calero MA, Diaz JP, Duan W, Diaz Z, Schroeder ED, Aparo S, Gatcliffe T, Albrecht F, Venkatappa S, Guardiola V, Garrido S, Rubens M, DeZarraga F, Vuong H. Pembrolizumab activity in patients with Fanconi anemia repair pathway competent and deficient tumors. Biomark Res. 2022 Jun 3;10(1):39. doi: 10.1186/s40364-022-00386-0.

Drugs

Indications