drugset / Trial / NCT03275558

Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma

NCT03275558

Phase 1 Withdrawn Center Trials & Treatment
Non-randomizedParallel-groupOpen-labelTreatment

Summary

This is a study to determine the efficacy, safety and clinical benefit (how well the drugs works), of the pharmaceutical compositions in Nasal Spray NST-4G for the treatment of brain tumors( Recurrent Glioblastoma, Gliosarcoma,Anaplastic Gliomas, Previously Treated). All drugs target the inhibition of the growth factors and neo-angiogenesis as one the main reasons for the growth of the tumor. The purpose of the Nasal Spray NST-4G study is to determine the safety and tolerability in order to establish the best dose level to be used in future studies.

Timeline

Start
2018-07-17
Primary completion
2018-07-17
Completion
2018-07-17

Drugs

EvaluationDrugModalityDoseRoute
Comparator Axitinib Small molecule 1 mg Intranasal
Comparator Pazopanib Small molecule 5 mg Intranasal
Comparator Sunitinib Small molecule 5 mg Intranasal

Indications