drugset / Trial / NCT03275558
Clinical Trial of the Use of the Nasal Spray of Patients With Recurrence of Glioblastoma
Non-randomizedParallel-groupOpen-labelTreatment
Summary
This is a study to determine the efficacy, safety and clinical benefit (how well the drugs works), of the pharmaceutical compositions in Nasal Spray NST-4G for the treatment of brain tumors( Recurrent Glioblastoma, Gliosarcoma,Anaplastic Gliomas, Previously Treated). All drugs target the inhibition of the growth factors and neo-angiogenesis as one the main reasons for the growth of the tumor. The purpose of the Nasal Spray NST-4G study is to determine the safety and tolerability in order to establish the best dose level to be used in future studies.
Timeline
- Start
- 2018-07-17
- Primary completion
- 2018-07-17
- Completion
- 2018-07-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Axitinib | Small molecule | 1 mg | Intranasal |
| Comparator | Pazopanib | Small molecule | 5 mg | Intranasal |
| Comparator | Sunitinib | Small molecule | 5 mg | Intranasal |