Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART)

Summary

Long-term beta-blocker therapy has not been investigated in contemporary randomized clinical trials in patients with myocardial infarction and normal heart function. The aim of this study is to determine whether long-term treatment with oral beta-blockade in patients with myocardial infarction and preserved left ventricular systolic ejection fraction reduces the composite of death of any cause or new myocardial infarction..

Timeline

Start

2017-09-11

Primary completion

2023-11-16

Completion

2025-12-31

Outcome

Missed primary endpoint

paper long-term beta-blocker treatment did not lead to a lower risk of the composite primary end point PMID 38587241 ↗

Publications

• Leissner P, Johansson M, Mars K, Held C, Hofmann R, Olsson EMG. Psychometric properties of the Swedish cardiac anxiety questionnaire: a Rasch analysis. Sci Rep. 2025 Nov 24;15(1):41834. doi: 10.1038/s41598-025-28073-8.
• Leening MJG, Boersma E. The perpetual need of randomized clinical trials: challenges and uncertainties in emulating the REDUCE-AMI trial. Eur J Epidemiol. 2024 Apr;39(4):343-347. doi: 10.1007/s10654-024-01127-3. Epub 2024 May 11.
• Matthews AA, Dahebreh IJ, MacDonald CJ, Lindahl B, Hofmann R, Erlinge D, Yndigegn T, Berglund A, Jernberg T, Hernan MA. Prospective benchmarking of an observational analysis in the SWEDEHEART registry against the REDUCE-AMI randomized trial. Eur J Epidemiol. 2024 Apr;39(4):349-361. doi: 10.1007/s10654-024-01119-3. Epub 2024 May 8.
• Yndigegn T, Lindahl B, Mars K, Alfredsson J, Benatar J, Brandin L, Erlinge D, Hallen O, Held C, Hjalmarsson P, Johansson P, Karlstrom P, Kellerth T, Marandi T, Ravn-Fischer A, Sundstrom J, Ostlund O, Hofmann R, Jernberg T; REDUCE-AMI Investigators. Beta-Blockers after Myocardial Infarction and Preserved Ejection Fraction. N Engl J Med. 2024 Apr 18;390(15):1372-1381. doi: 10.1056/NEJMoa2401479. Epub 2024 Apr 7.
• Humphries S, Mars K, Hofmann R, Held C, Olsson EMG. Randomized evaluation of routine beta-blocker therapy after myocardial infarction quality of life (RQoL): design and rationale of a multicentre, prospective, randomized, open, blinded endpoint study. Eur Heart J Open. 2023 Apr 10;3(3):oead036. doi: 10.1093/ehjopen/oead036. eCollection 2023 May.
• Granger CB, Pocock SJ, Gersh BJ. The need for new clinical trials of old cardiovascular drugs. Nat Rev Cardiol. 2023 Feb;20(2):71-72. doi: 10.1038/s41569-022-00819-1. No abstract available.

Drugs

Indications