drugset / Trial / NCT03293992

A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7058584 Following 7 Days of Instillation of Eye Drops in Patients With Primary Open Angle Glaucoma or Ocular Hypertension

NCT03293992

Phase 1 Completed 27 enrolled Hoffmann-La Roche
RandomizedParallel-groupDouble-blindTreatment

Summary

This is a Phase I, multi-center, randomized, adaptive, investigator/patient-masked, placebo-controlled, parallel multiple-ascending dose study (Part A) with an extension including up to two selected doses from Part A and latanoprost 0.005% as active comparator (Part B).

Timeline

Start
2017-10-10
Primary completion
2017-12-15
Completion
2017-12-21

Drugs

EvaluationDrugModalityDoseRoute
Subject Latanoprost Small molecule 0.005 % Topical
Subject RO7058584 Unknown 0.01 % Topical
Subject RO7058584 Unknown 0.1 % Topical
Subject RO7058584 Unknown 1 % Topical