drugset / Trial / NCT03295981
Local Bisphosphonate Effect on Recurrence Rate in Extremity Giant Cell Tumor of Bone
Phase 3
Recruiting
120 enrolled
St. Louis University
All India Institute of Medical Sciences · collabAllegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) · collabAmerican Academy of Orthopaedic Surgeons · collabBeth Israel Deaconess Medical Center · collabBoston Children's Hospital · collabIndiana University · collabJohns Hopkins University · collabMassachusetts General Hospital · collabMcGill University Health Centre/Research Institute of the McGill University Health Centre · collabOrthopedic Research and Education Foundation · collabThe Cleveland Clinic · collabUniversity of California · collabUniversity of Iowa · collabUniversity of Kansas · collabUniversity of Oklahoma · collabUniversity of Washington · collabWake Forest University · collab
RandomizedParallel-groupSingle-blindTreatment
Summary
The purpose of the clinical study is to investigate whether the local delivery of bisphosphonate as a surgical adjuvant can decrease the chance of a giant cell tumor of bone coming back to the same location. The hypothesis is that the local administration of bisphosphonate will decrease the rate of the tumor returning compared to traditional aggressive surgical removal of the tumor.
Timeline
- Start
- 2018-05-03
- Primary completion
- 2027-01
- Completion
- 2028-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Zoledronic acid | Other / unclassified | 4 mg | Other |