Peripheral Modulation of Muscle Stiffness and Spasticity

Summary

This is a single-center, double-blind, randomized, placebo-controlled, sequential Phase II trial of human recombinant hyaluronidase injections in individuals with post-stroke upper limb muscle stiffness. The investigators will recruit 56 subjects, who will be randomized to receive either the intervention or normal saline injections (first injection), and then the intervention the participants did not receive first (second injection). All individuals will receive the treatment by the end of the study.

Timeline

Start

2021-10-11

Primary completion

2026-06-26

Completion

2027-06-26

Drugs

Indications

No indication recorded.