Effect of Oxytocin Infusion on Blood Loss During Abdominal Myomectomy

NCT03308643 ↗

Phase 4 Completed 100 enrolled Kanuni Sultan Suleyman Training and Research Hospital

RandomizedParallel-groupDouble-blindPrevention

Summary

To evaluate the effects of oxytocin infusion during abdominal myomectomy.

Timeline

Start: 2017-10-01
Primary completion: 2018-05-10
Completion: 2018-05-10

Outcome

Met primary endpoint

paper Estimated intra-operative blood loss in the study group (189.5 ± 16.72 ml) was significantly lower than the placebo group (692.25 ± 89.93 ml) (95% CI 672.54-711.96; P < 0.0001). PMID 27862855 ↗

Publications

Results Atashkhoei S, Fakhari S, Pourfathi H, Bilehjani E, Garabaghi PM, Asiaei A. Effect of oxytocin infusion on reducing the blood loss during abdominal myomectomy: a double-blind randomised controlled trial. BJOG. 2017 Jan;124(2):292-298. doi: 10.1111/1471-0528.14416. Epub 2016 Nov 15.
Results Chang FW, Yu MH, Ku CH, Chen CH, Wu GJ, Liu JY. Effect of uterotonics on intra-operative blood loss during laparoscopy-assisted vaginal hysterectomy: a randomised controlled trial. BJOG. 2006 Jan;113(1):47-52. doi: 10.1111/j.1471-0528.2005.00804.x.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Oxytocin	Peptide	30 iu	Intravenous