Local Anesthetic Concentration and Nerve Block Duration

Summary

Background: Local anesthetic (LA) concentration and nerve block duration is sparsely described in a heterogenic study mass. Aim: To investigate the effect of LA concentration on peripheral nerve block duration in healthy volunteers. Methods: Randomization of 60 healthy volunteers who will receive 1 of 5 different volumes of LA (ropivacaine) using a constant dose. Primary endpoint: Sensory nerve block defined by insensitivity towards cold.

Timeline

Start

2017-10-04

Primary completion

2017-12-08

Completion

2018-01-05

Outcome

Missed primary endpoint

paper we found no changes in mean sensory nerve block duration. PMID 31789898 ↗

paper mean ± SD sensory block durations were 13.1 ± 2.7, 13.4 ± 3.3, 12.6 ± 3.9, 10.4 ± 2.9 and 11.0 ± 2.1 h (P = 0.073) PMID 31789898 ↗

Publications

• Christiansen CB, Madsen MH, Molleskov E, Rothe C, Lundstrom LH, Lange KHW. The effect of ropivacaine concentration on common peroneal nerve block duration using a fixed dose: A randomised, double-blind trial in healthy volunteers. Eur J Anaesthesiol. 2020 Apr;37(4):316-322. doi: 10.1097/EJA.0000000000001112.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ropivacaine	Other / unclassified	10 mg	Other

Indications

No indication recorded.