drugset / Trial / NCT03326986

Safety, Tolerability and Pharmacokinetics Study of MK-7252 in Healthy Adult Participants (MK-7252-001)

NCT03326986 ↗

Phase 1 Completed 24 enrolled Merck Sharp & Dohme LLC
RandomizedParallel-groupQuadruple-blindTreatment

Summary

The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of MK-7252 in healthy adults. Participants receive ascending doses of MK-7252 over five treatment periods. Each treatment period is separated by a 7-day washout period. Upon review of the interim safety and preliminary PK data of human exposure to date, Protocol Amendment 3 includes a third panel of participants, Panel C, to assess the PK of higher doses of MK-7252 and to assess the food effect of MK-7252.

Timeline

Start
2017-11-10
Primary completion
2018-12-17
Completion
2018-12-17

Drugs

EvaluationDrugModalityDoseRoute
Subject MK-7252 Unknown 1 mg Oral
Subject MK-7252 Unknown 3 mg Oral
Subject MK-7252 Unknown 6 mg Oral
Subject MK-7252 Unknown 12 mg Oral
Subject MK-7252 Unknown 24 mg Oral
Subject MK-7252 Unknown 48 mg Oral
Subject MK-7252 Unknown 72 mg Oral
Subject MK-7252 Unknown 108 mg Oral
Subject MK-7252 Unknown 120 mg Oral
Subject MK-7252 Unknown 162 mg Oral
Subject MK-7252 Unknown 180 mg Oral

Indications