drugset / Trial / NCT03326986
Safety, Tolerability and Pharmacokinetics Study of MK-7252 in Healthy Adult Participants (MK-7252-001)
RandomizedParallel-groupQuadruple-blindTreatment
Summary
The purpose of this study is to assess the safety, tolerability and pharmacokinetics (PK) of MK-7252 in healthy adults. Participants receive ascending doses of MK-7252 over five treatment periods. Each treatment period is separated by a 7-day washout period. Upon review of the interim safety and preliminary PK data of human exposure to date, Protocol Amendment 3 includes a third panel of participants, Panel C, to assess the PK of higher doses of MK-7252 and to assess the food effect of MK-7252.
Timeline
- Start
- 2017-11-10
- Primary completion
- 2018-12-17
- Completion
- 2018-12-17
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | MK-7252 | Unknown | 1 mg | Oral |
| Subject | MK-7252 | Unknown | 3 mg | Oral |
| Subject | MK-7252 | Unknown | 6 mg | Oral |
| Subject | MK-7252 | Unknown | 12 mg | Oral |
| Subject | MK-7252 | Unknown | 24 mg | Oral |
| Subject | MK-7252 | Unknown | 48 mg | Oral |
| Subject | MK-7252 | Unknown | 72 mg | Oral |
| Subject | MK-7252 | Unknown | 108 mg | Oral |
| Subject | MK-7252 | Unknown | 120 mg | Oral |
| Subject | MK-7252 | Unknown | 162 mg | Oral |
| Subject | MK-7252 | Unknown | 180 mg | Oral |