Nitrite Infusion in High Risk Patients Undergoing Cardiopulmonary Bypass

Summary

The main objective of this study is to evaluate the efficacy of intravenous sodium nitrite compared with placebo in reducing the occurrence of CSA-AK as diagnosed by KDIGO criteria during the first 72 hrs after cardiac surgery in high-risk patients undergoing cardiac surgery. Secondary objectives are to determine whether IV sodium nitrite achieves adequate pharmacokinetics (PK) in patients undergoing cardiac surgery with the use of CPB.

Timeline

Start

2018-10-01

Primary completion

2019-06-01

Completion

2020-12-01

Drugs

Indications