A Study of HS-196, an HSP90 Inhibitor-linked NIR Probe for Solid Malignancies

Summary

HS-196 is near infrared red (NIR)-tethered HSP90 inhibitor for clinical imaging of selective tumor binding. HS-196 consists of a HSP90 inhibitor that binds competitively to the Hsp90 ATP binding domain connected by a linker to a contrast agent (near infrared (NIR) dye) that can be used for imaging. HS-196 can freely enter tumor cells to selectively bind Hsp90. Due to the the NIR dye, HS-196 accumulation in the malignant cells allows for specific visualization of tumors within the body.

Timeline

Start

2018-08-10

Primary completion

2020-10-15

Completion

2022-09-07

Outcome

Outcome not reported

Stopped (Business): “Funding ended”

Drugs

Indications