Low-dose Ketamine and Postpartum Depression in Parturients With Prenatal Depression

Summary

Postpartum depression is common in mothers early after childbirth and produces harmful effects not only on mothers, but also on infants and young children. Parturients with prenatal depression are at increased of postpartum depression. Low-dose ketamine can be used for antidepressant therapy. We hypothesize that low-dose ketamine has a therapeutic effect on parturients with prenatal depression. This study is designed to investigate whether low-dose ketamine administered during cesarean delivery can decrease the incidence of postpartum depression in parturients with prenatal depression.

Timeline

Start

2017-11-23

Primary completion

2018-05-14

Completion

2018-06-25

Outcome

Missed primary endpoint

paper median 9 (interquartile range 6 to 13) with ketamine vs. 8 (6 to 10) with placebo; median difference 1, 95% CI -1 to 3; P = 0.608. PMID 36570810 ↗

paper A single low-dose ketamine infusion did not decrease the depression score at 2 days PMID 36570810 ↗

Publications

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Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.5 mg/kg	Intravenous

Indications