drugset / Trial / NCT03347292

Regorafenib Plus Pembrolizumab in First Line Systemic Treatment of HCC

NCT03347292

Phase 1 Completed 58 enrolled Bayer Merck Sharp & Dohme LLC · collab
Non-randomizedSequentialOpen-labelTreatment

Summary

This study will determine if the combination of regorafenib and pembrolizumab is safe and tolerated in patients with advanced liver cancer. In addition, the study will explore the anti-tumor activity of this combination as well as potentially identifying blood and tissue biomarkers associated with disease activity, status or response. The study will also investigate how the drugs behave in your body

Timeline

Start
2018-06-18
Primary completion
2020-12-17
Completion
2022-09-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Pembrolizumab Monoclonal antibody 200 mg Intravenous
Subject Regorafenib Small molecule 80 mg
Subject Regorafenib Small molecule 120 mg
Subject Regorafenib Small molecule 160 mg