drugset / Trial / NCT03353857
Drug-drug Interaction Between Rifampicin and Progestins/Ethinylestradiol and Midazolam
RandomizedParallel-groupOpen-labelOther
Summary
Quantify the effect of a probe CYP3A4 inducer (Rifampicin) on the pharmacokinetics of levonorgestrel, norethindrone, desogestrel, dienogest, drospirenone,estradiol and midazolam
Timeline
- Start
- 2017-11-29
- Primary completion
- 2018-07-04
- Completion
- 2019-02-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Desogestrel | Small molecule | 0.075 mg | — |
| Subject | Dienogest | Small molecule | 2 mg | — |
| Subject | Levonorgestrel | Small molecule | 0.03 mg | — |
| Subject | Midazolam | Small molecule | 1 mg | Oral |
| Subject | Norethindrone | Unknown | 0.35 mg | — |
| Subject | Rifampicin | Small molecule | 10 mg | — |
| Subject | Rifampicin | Small molecule | 600 mg | — |
| Subject | drospirenone | Unknown | 3 mg | — |
| Subject | ethinyl estradiol | Small molecule | 0.03 mg | — |
Indications
No indication recorded.